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GLP-1R can restore the mitochondrial membrane potential, promote ATP production, and reduce ROS production by activating the cAMP/PKA pathway (Signorile et al., 2022)

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Notably, nutraceuticals like RSV, PPR, and QUE have been shown to inhibit CYP3A4 activity, thereby reducing systemic drug elimination rates and increasing toxicity risks due to prolonged drug retention in circulation (9, 21, 32, 54)