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The increasing prevalence of obesity in T1DM is concurrently a consequence of a combination of variables, including genetic susceptibility to insulin resistance, the influence of an obesogenic environment, a sedentary lifestyle, as well as the impact of numerous biological, psychological and social stressors [18, 23]

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Muscle atrophy and sports medicine research&Wound healing and tissue engineering Indications: muscular dystrophy, AIDS related muscle consumption, muscle atrophy caused by long-term bed rest.Experimental Design:Animal model: Rats were subcutaneously injected with 0.1-0.3 mg/kg IGF-1 LR3, three times a week for 12 weeks, and the results showed a 15-20% increase in muscle strength.Cell experiment: In the myotube culture system, IGF 1 LR3 1mg can induce upregulation of myosin heavy chain (MyHC) expression and promote muscle fiber type transformation

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