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It may be hypothesized that there are five distinct binding sites, each associated with a specific class of prominent DPP-4 inhibitors

doi: 10.1016/j.bcp.2020.114150 65 CoskunTUrvaSRoellWCQuHLoghinCMoyersJSet al

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Early evidence already suggests that such multiplex regimens outperform single-agent therapy where metabolic heterogeneity blunts isolated responses (81, 85) (Table 3) Future work must dissect mechanism-specific dosing ratios, develop quantitative biomarkers of combinatorial efficacy, and deliver large, stratified, randomized trials to confirm both safety and clinical relevance